Health Care

Umbilical cord blood could slow brain's ageing, study suggests

Umbilical cord blood could slow brain's ageing, study suggests

On the other hand, blood from older individuals had no effect at all, while young adult blood had an intermediate effect. Long ago, researchers stitched mice together, connecting their circulatory systems, to show that young blood pumped into old mice could rejuvenate them. To test if this difference was functionally important, he infused plasma from each age group into the veins of 14-month-old mice every four days and two weeks later looked for changes in gene expression in the brain. They found several potential candidates, and injected them, one at a time, into the veins of old mice.

Stanford neuroscientist Joseph Castellano, lead author of the new study, told NPR, "The only thing, of course, is that it's a mouse experiment, and mouse experiments often don't actually translate faithfully into the human setting".

"Human blood, especially young human blood-the youngest we can obtain-has factors in there that can be beneficial in the brain", says Wyss-Coray. It's an exciting find in the field of regenerative medicine.

The problem is, they didn't label the proteins in cord blood to see if TIMP2 was the key protein, according to Conboy. There is no indication that it would work in humans.

Castellano concedes that "further studies will be needed to comprehensively characterize TIMP2 [levels and expression] over more precise age ranges and over varied demographic" groups, but defends its use in their study, as its effect on neuroplasticity appear positive and haven't been studied before. Some were in their 60s and 70s, others in their 20s.

American, Russian cheered as they reach Intl Space Station
Now on her third long-duration mission, she already holds the record for the most spacewalks conducted by a female astronaut. Moscow time on the same day, with Fyodor Yurchikhin of Roscosmos and Jack Fischer of NASA aboard.

The health Resources & Services Administration explains the umbilical cord and placenta are usually discarded but can be used to help people in need. Researchers are exploring this in a literal way as they study the effects of blood from human umbilical cords-which is about as young as it gets-on aging mice. They also showed numerous biochemical and physiological signs of rejuvenation in their

When the researchers injected TIMP2 into elderly mice, the results were almost identical to using the human umbilical cord blood. Removing TIMP2 from the umbilical cord blood before injecting them into mice did not result in any discernible benefit.


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